Warfarin dose requirements in a patient with theCYP2C9*14allele
نویسندگان
چکیده
منابع مشابه
Effect of ageing upon warfarin dose requirements: a longitudinal study.
This longitudinal study was designed to establish the rate of age-related change in warfarin dose requirements. Warfarin dosage was recorded retrospectively in 104 patients who had been stabilized on warfarin for a median period of 10 years (range 6-24 years) for prophylaxis of thromboembolic disease. There was a significant negative correlation between dosage and age at the start of therapy (p...
متن کاملEffect of patient-specific factors on weekly warfarin dose
OBJECTIVE To determine the influence of various patient-specific factors, use of concomitant medications, and weekly vitamin K intake on total weekly warfarin maintenance dose (TWD). METHODS Information collected, via retrospective chart review, included TWD, general demographics, vitamin K consumption, target INR range, use of alcohol, tobacco, and cytochrome P450 (CYP)-inducing medications,...
متن کاملThe effect of CYP2C9 and VKORC1 genetic polymorphisms on warfarin dose requirements in a pediatric population
OBJECTIVE The aim was to investigate the frequency of genetic polymorphisms of cytochrome P4502C9 (CYP2C9) and vitamin K epoxide reductase complex subunit1 (VKORC1) and determine the effect of these polymorphisms on warfarin dose requirements in pediatric patients. METHODS Fifty-eight pediatric patients with cardiac disease, thrombophilia, or other conditions, taking a stable warfarin dose, a...
متن کاملTitle: Genetic Factors Associated with Patient-specific Warfarin Dose in Ethnic Indonesians
1. I found it interesting that the clinical factors alone only accounted for 7.6% of the variability in dosing and were not significant but this moved to 27.5% with the addition of the genetic tests (p<0.05). Might be interesting to discuss this in the discussion (from Table 5). Also most prior studies have found that the combination of factors here account for 40% of the variability perhaps th...
متن کاملVKORC1 diplotype-derived dosing model to explain variability in warfarin dose requirements in Asian patients.
SUMMARY Warfarin-induced bleeding complications and high inter-patient variability are major hindrances to oral anticoagulant therapy. The present study identifies the influence of VKORC1 diplotypes, CYP2C9 and CYP2C19 variants on warfarin disposition and dose requirements in Chinese patients (n=107). The study subjects were genotyped for VKORC1, CYP2C9 and CYP2C19 polymorphic variants. Weekly ...
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ژورنال
عنوان ژورنال: Pharmacogenomics
سال: 2014
ISSN: 1462-2416,1744-8042
DOI: 10.2217/pgs.14.47